Magdalena E Sobieszczyk, MD

Infectious Disease
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Dr. Magdalena Sobieszczyk is the Harold Neu Professor of Infectious Diseases (in Medicine) at the Columbia University Medical Center. She is the Chief of Infectious Diseases at the Columbia University Irving Medical Center in New York. Dr. Sobieszczyk is a clinical virologist and the principal investigator of the NIH-funded Columbia Collaborative Clinical Trials Unit which has been advancing the science of HIV and emerging infections like SARS-CoV-2.

Areas of Expertise / Conditions Treated

  • HIV (Human Immunodeficiency Virus Infection)
  • HIV Medicine

Academic Appointments

  • Harold C. Neu Professor of Infectious Diseases (in Medicine) at the Columbia University Medical Center

Administrative Titles

  • Associate Fellowship Program Director
  • Chief, Division of Infectious Diseases

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Female

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180 Fort Washington Avenue
Suite 2-242
New York, NY 10032

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Credentials & Experience

Education & Training

  • Columbia University College of Physicians and Surgeons
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Board Certifications

  • Infectious Disease


Dr. Magdalena Sobieszczyk is the Harold Neu Professor of Infectious Diseases (in Medicine) at the Columbia University Medical Center. She is the Chief of Infectious Diseases at the Columbia University Irving Medical Center in New York. Dr. Sobieszczyk is a clinical virologist and the principal investigator of the NIH-funded Columbia Collaborative Clinical Trials Unit which has been advancing the science of HIV and emerging infections like SARS-CoV-2. Her research focuses on the development, testing, and implementation of biomedical interventions to prevent COVID-19 and HIV infections: specifically COVID-19 and HIV vaccines, monoclonal antibodies and pre-exposure prophylaxis (PrEP). She has led many large-scale NIH-funded international studies in these areas.

Her work also extends to testing interventions that address healthcare disparities and access to COVID-19 and HIV care and prevention. Since the start of the COVID-19 pandemic, she has established a prospective cohort to study epidemiology of COVID-19, cellular and antibody responses to primary infection and vaccination, and long-term effects of COVID-19 in diverse communities. She has led studies that focus on evaluating safety and efficacy of COVID-19 vaccines and other novel interventions to prevent and treat COVID-19. At the medical center, she is also overseeing the establishment of CUIMC clinical management guidelines for treatment of COVID-19 and a multidisciplinary approach to the care of patients with long-COVID. She has been involved in educational and community outreach efforts to increase engagement in and knowledge of COVID-19 vaccines. These efforts complement the ongoing clinical and research efforts that will further our understanding how to prevent and treat this infection. Her research with HIV infected individuals includes investigating gaps in the HIV prevention continuum and access to prevention services in the predominantly Latino and Black communities of northern Manhattan. The overarching aim of this body of research has been testing of interventions to support uptake, adherence and persistence to PrEP and successfully retain individuals in PrEP care. This work has focused on three key groups including adolescents and young adults, men who have sex with men and women at risk of HIV.

Research Interests

  • HIV prevention strategies, specifically clinical trials of preventive HIV vaccines

Selected Publications

  1. Falsey AR**, Sobieszczyk ME**, Hirsch I, Sproule S, Robb ML, Corey L, Neuzil KM, Hahn W, Hunt J, Mulligan MJ, McEvoy C, DeJesus E, Hassman M, Little SJ, Pahud BA, Durbin A, Pickrell P, Daar ES, Bush L, Solis J, Carr QO, Oyedele T, Buchbinder S, Cowden J, Vargas SL, Guerreros Benavides A, Call R, Keefer MC, Kirkpatrick BD, Pullman J, Tong T, Brewinski Isaacs M, Benkeser D, Janes HE, Nason MC, Green JA, Kelly EJ, Maaske J, Mueller N, Shoemaker K, Takas T, Marshall RP, Pangalos MN, Villafana T, Gonzalez-Lopez A; AstraZeneca AZD1222 Clinical Study Group. Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine. N Engl J Med. 2021 Dec 16;385(25):2348-2360. doi: 10.1056/NEJMoa2105290. Epub 2021 Sep 29. PMID: 34587382; PMCID: PMC8522798. (** contributed equally)
  2. Wang P, Nair MS, Liu L, Iketani S, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS, Mascola JR, Chang JY, Yin MT, Sobieszczyk M, Kyratsous CA, Shapiro L, Sheng Z, Huang Y, Ho DD. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. Nature. 2021 Mar 8. doi: 10.1038/s41586-021-03398-2. Epub ahead of print. PMID: 33684923.
  3. Zucker J, Gomez-Simmonds A, Purpura LJ, Shoucri S, LaSota E, Morley NE, Sovic BW, Castellon MA, Theodore DA, Bartram LL, Miko BA, Scherer ML, Meyers KA, Turner WC, Kelly M, Pavlicova M, Basaraba CN, Baldwin MR, Brodie D, Burkart KM, Bathon J, Uhlemann AC, Yin MT, Castor D, Sobieszczyk ME. Supervised Machine Learning Approach to Identify Early Predictors of Poor Outcome in Patients with COVID-19 Presenting to a Large Quaternary Care Hospital in New York City. J Clin Med. 2021 Aug 11;10(16):3523. doi: 10.3390/jcm10163523. PMID: 34441819; PMCID: PMC8397083.
  4. Mehta M, Purpura LJ, McConville TH, Neidell MJ, Anderson MR, Bernstein EJ, Dietz DE, Laracy J, Gunaratne SH, Miller EH, Cheng J, Zucker J*, Shah SS, Chaudhuri S, Gordillo CA, Patel SR, Guo TW, Karaaslan LE, Reshef R, Miko BA, Bathon JM, Pereira MR, Uhlemann AC, Yin MT, Sobieszczyk ME. What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak. PLoS One. 2021 Apr 8;16(4):e0249349. doi: 10.1371/journal.pone.0249349. PMID: 33831046; PMCID: PMC8031323
  5. Corey L, Gilbert PB, Juraska M, Montefiori DC, Morris L, Karuna ST, Edupuganti S, Mgodi NM, decamp AC, Rudnicki E, Huang Y, Gonzales P, Cabello. R, Orrell C, Lama JR,  Laher. F, Lazarus EM, Sanchez. J, Frank. I, Hinojosa J, Sobieszczyk ME, Marshall KE, Mukwekwerere PG, Makhema J, Baden LR, Mullins JI, Williamson C, Hural J, McElrath JM, Bentley C, Takuva S, Gomez Lorenzo MM, Burns DN, Espy N,  Randhawa AK, Kochar N, Piwowar-Manning EDonnell DJ, Sista N, Andrew P, Kublin JG, Gray G, Ledgerwood JE, Mascola JR, Cohen MS. Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition. N Engl J Med 2021; 384:1003-1014 DOI: 10.1056/NEJMoa2031738 
  6. Theodore DA*, Greendyke WG, Miko B, Whittier S, Green DA, Shoucri S*, Verna EC, Zucker J*, Sobieszczyk ME, Aaron JG, Scully BE, Saiman L, Pereira M, Furuya EY. Cycle Thresholds Among Solid Organ Transplant Recipients Testing Positive for SARS-CoV-2. Transplantation. 2021 Feb 15;. doi: 10.1097/TP.0000000000003695. [Epub ahead of print] PubMed PMID: 33606483
  7. Gulick RM, Sobieszczyk ME, Landry DW, Hollenberg AN. Prioritizing clinical research studies during the COVID-19 pandemic: lessons from New York City. J Clin Invest. 2020 Sep 1;130(9):4522-4524. doi: 10.1172/JCI142151. PMID: 32692726; PMCID: PMC7456231
  8. Geleris J,  Sun Y;  Platt J, Zucker J*, Baldwin M, Hripcsak G, Labella A, Manson DK, Kubin C, Barr RG, Sobieszczyk ME, Schluger NW. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl Med 2020. doi:10.1056/NEJMoa2012410 pmid:32379955
  9. Mgbako O, Miller EH, Santoro AF, Remien RH, Shalev N, Olender S, Gordon P, Sobieszczyk ME. COVID-19, Telemedicine, and Patient Empowerment in HIV Care and Research. AIDS Behav. 2020 May 21:1–4. doi: 10.1007/s10461-020-02926-x. Epub ahead of print. PMID: 32440970; PMCID: PMC7241062.
  10. Laracy J*, Zucker J*, Castor D, McMahon DJ, Guo TW, Yan M, Shalev N, Scherer M, Gordon P, Sobieszczyk M, Yin MT. HIV-1 Infection Does Not Change Disease Course or Inflammatory Pattern of SARS-CoV-2-Infected Patients Presenting at a Large Urban Medical Center in New York City. Open Forum Infect Dis. 2021 Jan 28;8(2):ofab029. doi: 10.1093/ofid/ofab029. PMID: 33604406; PMCID: PMC7880266.
  11. Shalev N, Scherer M, LaSota ED, Antoniou P, Yin MT, Zucker J, Sobieszczyk ME. Clinical Characteristics and Outcomes in People Living With HIV Hospitalized for COVID-19. Clin Infect Dis. 2020 May 30 doi: 10.1093/cid/ciaa635. Online ahead of print. PMID: 32472138
  12. Yumori C*, Zucker J*, Theodore D*, Chang M*, Carnevale C, Slowikowski J, LaSota E*, Olender S, Gordon P, Cohall A, Sobieszczyk ME. Women Are Less Likely to Be Tested for HIV or Offered Preexposure Prophylaxis at the Time of Sexually Transmitted Infection Diagnosis. Sex Transm Dis. 2021 Jan;48(1):32-36. doi: 10.1097/OLQ.0000000000001265. PMID: 33315784.
  13. Neidich SD,  Fong Y,  Sue Li SS,  Geraghty DE,  Williamson BD,  Young WC, Seaton KE, Shen X,  Sawant S, Zhang L,  deCamp AC,  Blette BS,  Shao M,  Yates N,  Feely F,  Pyo CW,  Ferrari G,  Frank I,  Karuna ST,  Swann E,  Mascola J,  Graham BS,  Hammer SM, Sobieszczyk ME, Lawrence Corey L, Janes H, McElrath MJ, Raphael Gottardo R, Peter B. Gilbert PB, Tomaras GD. Antibody Fc-Functions and IgG3 Associates with Decreased HIV-1 Risk. Journal of Clinical Investigation. 2019; 129 (11): 4838-4849.
  14. Zucker J, Carnevale C, Richards P, Slowikowski J, Borsa A, Gottlieb F, Vakkur I, Hyden C, Olender S, Cohall A, Gordon P, Sobieszczyk ME. Predictors of Disengagement in Care for Individuals Receiving Pre-Exposure Prophylaxis (PrEP). J Acquir Immune Defic Syndr. 2019 Apr 11
  15. Zucker J, Patterson B, Ellman T,  Slowikowski J, Olender S, Gordon P, Morrison E, Sobieszczyk ME. Missed Opportunities for Engagement in the Prevention Continuum in a Predominantly Black and Latino Community in New York City. AIDS Patient Care and STDs. AIDS Patient Care and STDs. AIDS Patient Care STDS. 2018 Nov;32(11):432-437
  16. McPherson TD, Sobieszczyk ME, Markowitz M.Cabotegravir in the treatment and prevention of Human Immunodeficiency Virus-1. Expert Opin Investig Drugs. 2018 Apr;27(4):413-420
  17. Zucker J, Carnevale C, Rai AJ, Gordon P, Sobieszczyk ME. Positive or Not, that is the Question: HIV Testing for Individuals on Pre-Exposure Prophylaxis (PrEP). J Acquir Immune Defic Syndr. 2018 Feb 21.
  18. Meyers K.; Rodriguez K.; Brill AL.; Wu Y.; La Mar M.; Dunbar D.; Koblin B.; Margolis D.; Sobieszczyk ME.; Tieu HV.; Frank I.; Markowitz M.; Golub SA. Lessons for Patient Education Around Long-Acting Injectable PrEP: Findings from a Mixed-Method Study of Phase II Trial Participants. AIDS and Behavior. 2017
  19. Sobieszczyk ME, Werner L, Mlisana K, Naicker N, Feinstein A, Gray CM, Masson L, Passmore JS, Williamson C, Karim QA, Abdool Karim SS, Garret NJ. Metabolic syndrome after HIV acquisition in South African women. J Acquir Immune Defic Syndr. 2016 Jul 6. [Epub ahead of print]
  20. Tang EC, Galea JT, Kinsler JJ, Gonzales P, Sobieszczyk ME, Sanchez J, Lama JR. Using Conjoint Analysis to Determine the Impact of Product and User Characteristics on Acceptability of Rectal Microbicides for HIV Prevention among Peruvian Men Who Have Sex with Men. Accepted. Sexually Transmitted Infections. Sex Transm Infect 2016 May 16;92(3):200-5.
  21. Williams WB, Liao HX, Moody MA, Kepler TB, Alam SM, Gao F, Wiehe K, Trama AM, Jones K, Zhang R, Song H, Marshall DJ, Whitesides JF, Sawatzki K, Hua A, Liu P, Tay MZ, Seaton KE, Shen X, Foulger A, Lloyd KE, Parks R, Pollara J, Ferrari G, Yu JS, Vandergrift N, Montefiori DC, Sobieszczyk ME, Hammer S, Karuna S, Gilbert P, Grove D, Grunenberg N, McElrath MJ, Mascola JR, Koup RA, Corey L, Nabel GJ, Morgan C, Churchyard G, Maenza J, Keefer M, Graham BS, Baden LR, Tomaras GD, Haynes BF. HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. Science. 2015 Aug 14;349(6249):aab1253. Epub 2015 Jul 30.
  22. Dawson L, Garner S, Anude C, Ndebele P, Karuna S, Holt R, Broder G, Handibode J, Hammer S, Sobieszczyk ME. Testing the waters: ethical considerations for including PrEP in a phase IIb HIV vaccine efficacy trial. Clinical trials. Apr 7, 2015.
  23. Ellman TM, Hawkins K, Benitez J, Negron R, Chang S, Palmer S, Robertson V, Chiasson MA, Sobieszczyk ME. Representation of Latino and Black Men and Transgender women Screening and Enrolling into Preventive HIV Vaccine Trials in New York City. Vaccine. 2015;33(48):6809-15.
  24. Tang E., Sobieszczyk ME., Shu E., Gonzalez P., Sanchez J., Lama J. Provider Attitudes toward Oral Pre-Exposure Prophylaxis for HIV Prevention among High-Risk MSM in Lima, PeruAIDS Research and Human Retroviruses 30(5):416-24.2014
  25. Ellman TM, Sexton ME, Warshafsky D, Sobieszczyk ME, Morrison E.  A Forgotten Population: Older Adults Newly-Diagnosed with HIV. AIDS Patient Care and STDs. Volume 28, Number 10, 2014
  26. Hammer S.M., Sobieszczyk ME, Janes H. et al. Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine. New England J of Medicine, 2013 10.1056/NEJMoa1310566.
  27. Tieu HV, Rolland M, Hammer SM, Sobieszczyk ME. Translational Research Insights from Completed HIV Vaccine Efficacy Trials. Journal of AIDS 2013; (63) Supplement 2, July 1
  28. Mlisana K, Sobieszczyk ME, Loggerenberg F, Feinstein A, Werner L, Feinstein A, Williamson C, Loggerenberg F, Karim S. Challenges of diagnosing acute HIV-1 subtype C infection in African women: Performance of a clinical algorithm and the need for point-of-care nucleic acid based testing. PLoS ONE 2013; 8(4): e62928.
  29. Janes H, Gilbert P, Buchbinder S, Kublin J, Sobieszczyk ME, and Hammer SM. In Pursuit of an HIV Vaccine: Designing Efficacy Trials in the Context of Partially Effective Nonvaccine Prevention Modalities. AIDS Research and Human Retroviruses 2013. ahead of print. doi:10.1089/aid.2012.0385